Intracellular Interactions Between Arboviruses and Wolbachia in Aedes aegypti

Aedes aegypti is inherently susceptible to arboviruses. The geographical expansion of this vector host species has led the persistence Dengue, Zika, and Chikungunya human infections. These viruses take advantage mosquito’s cell create an environment conducive for their growth. Arboviral infection triggers transcriptomic protein dysregulation in Ae. effect, antiviral mechanisms are compromised. Currently, there no existing vaccines able protect hosts from these infections thus, control strategies such as Wolbachia mass release program regarded a viable option. Considerable evidence demonstrates how presence interferes with arboviruses by decreasing cytoskeletal proteins lipids essential arboviral infection. Also, strengthens immunity, cellular regeneration causes expression microRNAs which could potentially be involved virus inhibition. However, variation magnitude ’s pathogen blocking effect that not due endosymbiont’s density been recently reported. Furthermore, phenotype differs depending on strain species. This prompts need explore interactions between -arboviruses- different strains overall affect cell. Understanding what happens at molecular level will provide sustainability control.